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2 edition of effect of phencyclidine on the uptake and release of dopamine in striatal tissue found in the catalog.

effect of phencyclidine on the uptake and release of dopamine in striatal tissue

Thomas Edward Ary

effect of phencyclidine on the uptake and release of dopamine in striatal tissue

by Thomas Edward Ary

  • 348 Want to read
  • 23 Currently reading

Published .
Written in English

    Subjects:
  • Phencyclidine.

  • Edition Notes

    Statementby Thomas Edward Ary.
    The Physical Object
    Paginationx, 64 leaves ;
    Number of Pages64
    ID Numbers
    Open LibraryOL16515874M

    A majority of the non-human primate studies (three out of four) showed no effect of ketamine on dopamine levels in the cortex or striatal regions (Supplementary Table 6). 34, 35, 36 One study. Abstract. In order to obtain a more complete understanding of pyrethroid neurotoxicity, effects of the pyrethroid insecticides, allethrin (type I), cyhalothrin (type II) and deltamethrin (type II) on extracellular levels of dopamine (DA) and its metabolites in the striatum of .

      Stereoselective effects of ketamine on DA release in rat striatal slices have been reported (Hancock and Stamford, ; Tso et al., ). Thus, although overall changes in extracellular DA concentrations have been assessed previously, there is no consensus effect, and the low temporal resolution of microdialysis does not permit a. Amperozide inhibited the amphetamine-stimulated release of dopamine from perfused rat striatal tissue in a dose-dependent manner. With 1 and 10 {mu}m amperozide there was significant inhibition of the amphetamine-stimulated release of dopamine, to 44 and 36 % of control.

    1. The effects of single-dose regimens of amphetamine, cocaine, nomifensine and GBR on the dynamics of dopamine (DA) release and metabolism were evaluated in the frontal cortex, hypothalamus, nucleus accumbens and striatum. The regimens selected are known to produce substantial behavioural effects. We have investigated the effects of a schizophrenomimetic drug phencyclidine (PCP) and N‐methyl‐ D ‐aspartate (NMDA)‐related agents alone or in combination on dopamine metabolism in the medial prefrontal cortex and striatum of the rats by measuring the tissue concentrations of dopamine and its metabolite, 3,4‐dihyroxyphenylacetic acid (DOPAC), and the rate of dopamine disappearance.


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Effect of phencyclidine on the uptake and release of dopamine in striatal tissue by Thomas Edward Ary Download PDF EPUB FB2

The ability of phencyclidine (PCP), amphetamine and other substances to stimulate dopamine release from and inhibit dopamine uptake into rat striatal synaptosomes was examined in a continuous superfusion system. Inhibition of uptake was measured by determining inhibition of [3H]dopamine displacement by unlabeled dopamine ([1H]dopamine).Cited by: The effect of PCP on 'H-DA release from striatal slices vitro In order to assess the DA releasing properties of PCP, we studied its effect on the release PHENCYCLIDINE AND STRIATAL DOPAMINE TABLE 1 The effect of PCP on the rate of striatal DOPA formation in rats pretreated with by: Phencyclidine (PCP) is an abused drug which produces untoward side-effects (violent behavior, hallucinations and paranoia) resembling certain forms of schizophrenia (Rawson et al., ).

Uptake and Release of Dopamine from Rat Striatal Slices: Comparison of PCP, Amphetamine and Nomifensine | SpringerLinkCited by: 6. Phencyclidine was examined for its ability to release [3 H]dopamine ([3 H]DA) from prelabelled chopped rat striatal tissue.

A dynamic perfusion system was used in order to minimize the effects of drugs on uptake mechanisms. Cocaine and S-(+)-amphetamine were used to distinguish uptake inhibition from a neurotransmitter releasing by: Phencyclidine was examined for its ability to release [3H]dopamine ([3H]DA) from prelabelled chopped rat striatal tissue.

A dynamic perfusion system was used in order to minimize the effects of drugs on uptake mechanisms.

Cocaine and S-(+)-amphetamine were used to distinguish uptake inhibition from a neurotransmitter releasing by: Phencyclidine was examined for its ability to release [3H]dopamine ([3H]DA) from prelabelled chopped rat striatal tissue.

A dynamic perfusion system was used in order to minimize the effects of drugs on uptake mechanisms. Cocaine and S-(+)-amphetamine were used to distinguish uptake inhibition from a neurotransmitter releasing action.

Journals & Books; Register Sign in Sign inCited by: To examine effects of continuous PCP administration on dopamine autoreceptor function, release of [3H]dopamine in response to electrical stimulation and in the presence of a dopamine agonist or antagonist was tested in striatal and prefrontal cortical tissue.

Autoreceptor responses were similar in control and PCP-treated tissues. Effects of the major metabolite of phencyclidine, the trans isomer of 4-phenyl (1-piperidinyl)cyclohexanol, on [3H]N- (1- [2-thienyl]cyclohexyl)-3,4-piperidine ([3H]TCP) binding and [3H]dopamine uptake in the rat brain - ScienceDirect.

Phencyclidine (PCP) rapidly (within 1 h) increased vesicular dopamine uptake and binding of the vesicular monoamine transporter-2 (VMAT-2) ligand, dihydrotetrabenazine.

Phencyclidine (PCP) produces many profound effects in the central nervous system. PCP has numerous behavioral and neurochemical effects such as inhibiting the uptake and facilitating the release of dopamine, serotonin, and norepinephrine.

PCP also interacts with sigma, mu opioid, muscarinic, and nicotinic receptors. However, the psychotomimetic effects induced by PCP are believed to be. Can A, Zanos P. Effects of ketamine and ketamine metabolites on evoked striatal dopamine release, dopamine receptors, and monoamine transporters.

J Pharmacol Exp Ther. ;– CAS. In vivo microdialysis was used to study the effects of systemically administered phencyclidine (PCP, 10 mg/kg) on the extracellular levels of dopamine, dihydroxyphenylacetate (DOPAC), homovanillate (HVA), 5-hydroxy-indolacetate (5-HIAA), γ-aminobutyrate (GABA), glutamate, and aspartate in the rat dorsolateral striatum.

In order to demarcate the effects of anesthesia, tissue trauma and gliosis. Uptake of dopamine and releasing amines, and the release of [3H]dopamine induced by these amines in striatal homogenates is: temperature dependent, saturable, stereoselective, sensitive to.

In slices prepared from reserpine-pretreated rats, the metaphit ( microM)-induced outflow was reduced to that observed with 10 microM nomifensin, suggesting a vesicular releasing effect of metaphit in addition to dopamine uptake by: Holmes, J.

and Rutledge, C. () Effects of the d-and l-isomers of amphetamine on uptake, release and catabolism of norepinephrine, dopamine and 5-hydroxytryptamine in several regions of rat brain.

Biochem. Pharmacol. 25, – PubMed CrossRef Google Scholar. Effects of phencyclidine on extracellular levels of dopamine, dihydroxyphenylacetic acid and homovanillic acid in conscious and anesthetized rats.

Effects of phencyclidine, amphetamine and related compounds on dopamine release from and uptake into striatal synaptosomes. Bowyer. Pharmac. exp. Ther. Mice were decapitated and the striatal tissue (approximately 8–10 mg) was dissected out and incubated for 60 min in Mg 2+-containing ml of Krebs bicarbonate buffer containing – μCi.

Amantadine is an antiviral agent found to have an antiparkinsonian effect with several proposed mechanisms of action. These include the release of dopamine from central neurons, delay of dopamine uptake by neural cells, blockade of N-methyl d-aspartate (NMDA) receptors, and anticholinergic effects.

As monotherapy or in combination with other antiparkinsonian medications, it is given at a. The effect of five daily intraperitoneal (i.p.) injections of NT69L on in vitro dopamine release, uptake, and [(3)H]NT binding in rat striatal tissue was investigated.

The effect of sevoflurane on the release of neurotransmitters such as dopamine, glutamate and aspartate has been investigated by Toner et al.

[25] They reported that when sevoflurane [email protected]{osti_, title = {Phencyclidine (PCP)-like inhibition of N-methyl-D-aspartate-evoked striatal acetylcholine release, /sup 3/H-TCP binding and synaptosomal dopamine uptake by metaphit, a proposed PCP receptor acylator}, author = {Snell, L D and Johnson, K M and Yi, S J and Lessor, R A and Rice, K C and Jacobson, A E}, abstractNote = {The phencyclidine (PCP) receptor acylator.

We now investigate the effects of clozapine on the dopamine projections to prefrontal cortex, nucleus accumbens, and striatum in control monkeys and in .